Tesamorelin (2mg) Dosage Protocol
Tesamorelin is a growth hormone-releasing hormone (GHRH) analog FDA-approved as Egrifta for reducing visceral adipose tissue in HIV-infected patients with lipodystrophy. It stimulates natural GH production.
Add 2.0 mL bacteriostatic water → 1 mg/mL (1000 mcg/mL)
2mg once daily (FDA-approved dose)
At 1 mg/mL: 100 units = 1mg, full vial = 2mg
Lyophilized: -20°C; Reconstituted: 2-8°C, use within 14 days
| Week | Daily Dose | Units (per injection) |
|---|---|---|
| Daily | 2mg | 200 units (full vial) |
| Timing | Once daily | Abdomen injection |
| Duration | Continuous | Per prescriber guidance |
- 1Draw 2.0 mL bacteriostatic water with a sterile syringe
- 2Inject slowly down the vial wall to prevent foaming
- 3Gently swirl until fully dissolved - do not shake
- 4Label with date and concentration, refrigerate immediately
Tesamorelin is a synthetic GHRH analog that stimulates pituitary GH release. Clinical trials (26-week studies) demonstrated significant reduction in trunk fat (-15.2%) and visceral adipose tissue. It increases IGF-1 levels and improves body composition without affecting subcutaneous fat.
- FDA-approved for visceral fat reduction in HIV lipodystrophy
- Reduces trunk fat by approximately 15%
- Increases lean body mass
- Improves triglyceride levels in some patients
- Stanley TL, et al. Effect of tesamorelin on visceral fat. JAMA. 2014;312(4):380-9
- Falutz J, et al. Recombinant human GHRH in HIV lipodystrophy. JAIDS. 2010;53(3):311-22
- FDA Prescribing Information - Egrifta (tesamorelin) injection
- Dhillon S. Tesamorelin: a review. Drugs. 2011;71(8):1071-91
Lyophilized
Store at -20°C, protected from light
Reconstituted
Refrigerate at 2-8°C, use within 14 days
Rotate injection sites within abdominal area
- •FDA-approved as Egrifta for specific indication
- •May cause fluid retention and joint pain
- •Contraindicated in active malignancy
- •Anti-tesamorelin antibodies develop in ~50% of patients
Disclaimer: This content is intended for research and educational purposes only. Not intended to diagnose, treat, cure, or prevent any disease. All compounds are for research use only. Dosing information is derived from published scientific literature and clinical studies.