SS-31 (Elamipretide) (5mg) Dosage Protocol
SS-31 (Elamipretide) is a mitochondria-targeted tetrapeptide that concentrates in the inner mitochondrial membrane. It has been studied in clinical trials for heart failure and mitochondrial myopathy.
Add 2.0 mL bacteriostatic water → 2.5 mg/mL
0.25 mg/kg or 10-40mg daily based on clinical trials
At 2.5 mg/mL: 40 units = 1mg
Lyophilized: -20°C; Reconstituted: 2-8°C for up to 4 weeks
| Week | Daily Dose | Units (per injection) |
|---|---|---|
| Clinical Trials | 0.25 mg/kg | IV or SC |
| Research | 10-40mg daily | Subcutaneous |
| Duration | Per protocol | Varies by indication |
- 1Draw 2.0 mL bacteriostatic water with a sterile syringe
- 2Inject slowly down the vial wall to prevent foaming
- 3Gently swirl until fully dissolved - do not shake
- 4Label with date and concentration, refrigerate immediately
SS-31 targets cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure and optimizing electron transport chain function. It reduces reactive oxygen species production and improves ATP synthesis. Phase 2/3 trials have evaluated it for heart failure and Barth syndrome.
- Targets and protects mitochondria
- Reduces oxidative stress
- Studied for heart failure and mitochondrial diseases
- May improve exercise capacity
- Szeto HH. First-in-class cardiolipin-protective compound. Br J Pharmacol. 2014;171(8):2029-50
- ClinicalTrials.gov NCT02814097 - Elamipretide in heart failure
- Karaa A, et al. Elamipretide in mitochondrial myopathy. Neurology. 2023;101(3):e238-e252
- Butler J, et al. Effects of elamipretide on HFrEF. Circ Heart Fail. 2020;13(5):e006796
Lyophilized
Store at -20°C, protected from light
Reconstituted
Refrigerate at 2-8°C, use within 4 weeks
Protect from light during storage and handling
- •Investigational drug - not FDA approved
- •Multiple clinical trials completed and ongoing
- •Developed by Stealth BioTherapeutics
- •Orphan drug designation for Barth syndrome
Disclaimer: This content is intended for research and educational purposes only. Not intended to diagnose, treat, cure, or prevent any disease. All compounds are for research use only. Dosing information is derived from published scientific literature and clinical studies.