Semax (5mg) Dosage Protocol
Semax is a synthetic heptapeptide analog of ACTH(4-10) developed in Russia. It is approved there for stroke, cognitive disorders, and optic nerve disease. It has nootropic and neuroprotective properties.
Add 5.0 mL bacteriostatic water → 1 mg/mL (1000 mcg/mL)
200-600 mcg intranasally, 2-3x daily
At 1 mg/mL: 20 units = 200 mcg, 60 units = 600 mcg
Lyophilized: -20°C; Reconstituted: 2-8°C for up to 4 weeks
| Week | Daily Dose | Units (per injection) |
|---|---|---|
| Standard | 200-300 mcg | 2-3 times daily intranasal |
| Higher Dose | 600 mcg | 2-3 times daily |
| Duration | 10-14 days | Per cycle |
- 1Draw 5.0 mL bacteriostatic water with a sterile syringe
- 2Inject slowly down the vial wall to prevent foaming
- 3Gently swirl until fully dissolved - do not shake
- 4Label with date and concentration, refrigerate immediately
Semax is an ACTH(4-10) analog that increases BDNF and NGF expression, enhances attention and memory, and provides neuroprotection. It modulates dopaminergic and serotonergic systems. Russian clinical use includes stroke recovery, cognitive disorders, and optic nerve atrophy.
- Approved in Russia for stroke and cognitive disorders
- Increases BDNF and neurotrophic factors
- Enhances attention and memory
- Neuroprotective properties
- Eremin KO, et al. Semax and cognitive function. Neurosci Behav Physiol. 2005;35(6):611-7
- Dolotov OV, et al. Semax and neurotrophins. Neurochem Res. 2006;31(3):341-8
- Gusev EI, et al. Semax in stroke treatment. Zh Nevrol Psikhiatr Im S S Korsakova. 1997;97(6):26-34
Lyophilized
Store at -20°C, protected from light
Reconstituted
Refrigerate at 2-8°C, use within 4 weeks
Intranasal administration is standard
- •Approved in Russia - not FDA approved
- •Intranasal administration preferred
- •No significant side effects reported
- •May be combined with Selank
Disclaimer: This content is intended for research and educational purposes only. Not intended to diagnose, treat, cure, or prevent any disease. All compounds are for research use only. Dosing information is derived from published scientific literature and clinical studies.