MOTS-c (10mg) Dosage Protocol
MOTS-c is a mitochondrial-derived peptide encoded by the 12S rRNA gene. Research indicates it regulates metabolic homeostasis, enhances insulin sensitivity, and mimics exercise effects on metabolism.
Add 2.0 mL bacteriostatic water → 5 mg/mL (5000 mcg/mL)
5-10mg, 3-5 times weekly
At 5 mg/mL: 100 units = 5mg, 200 units = 10mg
Lyophilized: -20°C; Reconstituted: 2-8°C for up to 4 weeks
| Week | Daily Dose | Units (per injection) |
|---|---|---|
| Weeks 1-2 | 5mg 3x weekly | 100 units per dose |
| Weeks 3-4 | 5mg 5x weekly | 100 units per dose |
| Weeks 5+ | 10mg 3-5x weekly | 200 units per dose |
- 1Draw 2.0 mL bacteriostatic water with a sterile syringe
- 2Inject slowly down the vial wall to prevent foaming
- 3Gently swirl until fully dissolved - do not shake
- 4Label with date and concentration, refrigerate immediately
MOTS-c is a 16-amino acid peptide that activates AMPK pathway, enhances glucose uptake, and improves mitochondrial function. Mouse studies used 0.5 mg/kg/day IP. It is considered an exercise mimetic that improves insulin sensitivity and prevents diet-induced obesity. Phase 1 trials of analog CB4211 have been conducted.
- Enhances insulin sensitivity and glucose metabolism
- Exercise mimetic - improves metabolic markers
- Supports mitochondrial function
- May improve physical performance in aging
- Lee C, et al. MOTS-c promotes metabolic homeostasis. Cell Metab. 2015;21(3):443-54
- Reynolds JC, et al. MOTS-c is an exercise-induced peptide. Nat Commun. 2021;12(1):595
- Kong BS, et al. MOTS-c, diabetes, and aging. Diabetes Metab J. 2023;47(3):315-24
- Zheng Y, et al. MOTS-c: A promising peptide. Front Endocrinol. 2023;14:1120533
Lyophilized
Store at -20°C, protected from light
Reconstituted
Refrigerate at 2-8°C, use within 4 weeks
Best administered in the morning or pre-exercise
- •Research compound - not FDA approved
- •Endogenous levels increase with exercise
- •May support weight management efforts
- •Phase 1 clinical trials ongoing for analogs
Disclaimer: This content is intended for research and educational purposes only. Not intended to diagnose, treat, cure, or prevent any disease. All compounds are for research use only. Dosing information is derived from published scientific literature and clinical studies.