AICAR (50mg) Dosage Protocol
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is an AMP-activated protein kinase (AMPK) activator. Research has explored its effects on cellular energy metabolism, endurance, and metabolic pathways.
Add 2.0 mL bacteriostatic water → 25 mg/mL
150-500 mg daily, based on research protocols
At 25 mg/mL: 20 units = 500 mg per injection
Lyophilized: -20°C; Reconstituted: 2-8°C for up to 2 weeks
| Week | Daily Dose | Units (per injection) |
|---|---|---|
| Weeks 1-2 | 150 mg daily | 6 units (0.06 mL) |
| Weeks 3-4 | 300 mg daily | 12 units (0.12 mL) |
| Weeks 5-8 | 500 mg daily | 20 units (0.2 mL) |
- 1Draw 2.0 mL bacteriostatic water with a sterile syringe
- 2Inject slowly down the vial wall
- 3Gently swirl until fully dissolved
- 4Label with date and concentration, refrigerate immediately
AICAR is an analog of AMP that activates AMPK, a master regulator of cellular energy homeostasis. AMPK activation promotes glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. Research in animal models showed improved endurance and metabolic parameters.
- Activates AMPK pathway
- Research suggests metabolic benefits
- May support cellular energy production
- Studied for endurance applications
- Narkar VA, et al. AMPK and PPARδ Agonists. Cell. 2008;134(3):405-15
- Winder WW, Hardie DG. AMP-activated protein kinase. Am J Physiol. 1999
- AICAR clinical research and AMPK activation studies
Lyophilized
Store at -20°C, protected from light
Reconstituted
Refrigerate at 2-8°C, use within 2 weeks
Less stable than many peptides - use promptly
- •Research compound - not FDA approved
- •Banned by WADA for athletic competition
- •May affect blood glucose - monitor if diabetic
- •Use within 2 weeks of reconstitution
Disclaimer: This content is intended for research and educational purposes only. Not intended to diagnose, treat, cure, or prevent any disease. All compounds are for research use only. Dosing information is derived from published scientific literature and clinical studies.